Anuradha Vajjala

Anuradha Vajjala

Ph.D. Nanyang Technological University
M.S. University of Hyderabad

B.S. Osmania University
anuradha002 [at] e.ntu.edu.sg

 

I just completed my PhD in the Kline lab, in the microbial pathogenesis of group A streptococcus in infectious diseases, and am currently working in SCELSE as a Research Fellow. I have a Master’s degree from University of Hyderabad and a Bachelor’s degree from Osmania University, India, both specializing in biochemistry. I have an extensive research experience with specialization in muscle biology as well as bacterial biofilms in infectious diseases. When I am not in the lab, I enjoy reading, with special interest in post-colonial literature and classics. I am also an avid art enthusiast and blogger and love to travel and cook for friends.

During my PhD, I developed in vitro and in vivo models to characterize biofilm formation by a necrotizing strain of group A Streptococcus (GAS), in collaboration with Dr Emanuel Hanski, my co-supervisor from Hebrew University, Jerusalem. GAS causes a wide range of skin and throat infections, but is also involved in fulminant and systemic infections like toxic shock syndrome and necrotizing fasciitis (NF), also known as the “flesh eating disease”. My studies delineated molecular determinants of biofilm formation during NF by a necrotizing strain of GAS in the host, and I demonstrated a novel role of GAS secreted streptolysins in this event thereby establishing a link between bacterial pathogenesis and biofilm formation.

1. Negative auto-regulation of myostatin expression is mediated by Smad3 and microRNA-27.; McFarlane C, Vajjala A, Arigela H, Lokireddy S, Ge X, Bonala S, Manickam R, Kambadur R, Sharma M.; PLoS One. 2014 Jan 31;9(1)
2. Lack of Smad3 signaling leads to impaired skeletal muscle regeneration. Ge X, Vajjala A, McFarlane C, Wahli W, Sharma M, Kambadur R.; Am J Physiol Endocrinol Metab. 2012 Jul 1; 303(1)
3. Smad3 signaling is required for satellite cell function and myogenic differentiation of myoblasts. Ge X, McFarlane C, Vajjala A, Lokireddy S, Ng ZH, Tan CK, Tan NS, Wahli W, Sharma M, Kambadur R.; Cell Res. 2011 Nov; 21(11):1591-604
4. Streptolysin-induced endoplasmic reticulum stress drives group A streptococcal in vivo biofilm formation. (in preparation).

  1. 60th Nobel Conference on Biofilm formation, its clinical impact and potential treatment (Karolinska Institutet, Stockholm, Sweden; Aug, 2013)
  2. Research Innovation in Infectious and Inflammatory Diseases, CREATE Joint Symposium (HUJ, Israel, NUS, Singapore, Singapore-MIT Alliance for Research and Technology, SMART; July 2013)
  3. 7th APOCB (Asia Pacific Organization of Cell Biology) Congress and ASCB workshop, Biopolis, A*STAR, Singapore; Feb 2014)
  4. Gordon Research Seminar/Conference on Bacterial Toxins and Pathogenicity (Waterville Valley, New Hampshire; USA, Jul 9th-15th, 2016)