Ch’ng Jun Hong

Ch’ng Jun Hong

PhD, National University Singapore
Advisor: Kevin Tan

Visiting Research Fellow

During my PhD at National University of Singapore (2008-2012), I worked with A/Prof Kevin Tan on the malaria parasite, Plasmodium falciparum, and characterized a drug-induced cell death pathway. We also developed a screen for compounds that reverse chloroquine resistance. I went on to work with Prof Mats Wahlgren during my postdoc at Karolinska Institute (2013-2016), where I studied the phenomenon of P. falciparum-induced erythrocyte aggregation called rosetting and developed a cytometry-based screen for rosette-disrupting compounds. I have three kids and enjoy being with them but also being away from them! Also enjoy cycling, ultimate, soccer, fishing, playing the drums and guitar. Holding a joint appointment with NUS-SCELSE, my project in the Kline lab will investigate the role or polymicrobial infections in wound models and elucidate the basis of inter-species growth enhancement. My primary appointment is Instructor at the Department of Microbiology and Immunology at NUS.

 

1. Frequent GU wobble pairings reduce translation efficiency in Plasmodium falciparum. Chan CLS, Ch’ng JH, Wahlgren M, Thutkawkorapin J. Nature Scientific Reports. 2017; 7(1): 723
2. Epitopes of anti-RIFIN antibodies and characterization of rif-expressing Plasmodium falciparum parasites by RNA sequencing. Ch’ng JH, Sirel M, Zandian A, Quintana MdP, Chan CLS, Moll K, Tellgren-Roth A, Nilsson IM, Qundos U, Nilsson P, Wahlgren M. Nature Scientific Reports 2017; 7, 43190.
 3. Development of drug-loaded immunoliposomes for the selective targeting and elimination of rosetting Plasmodium falciparum-infected red blood cells. Moles E, Moll K, Ch’ng JH, Parini P, Wahlgren M, Fernandez-Busquets X. Journal of Controlled Release. 2016; 241:57-67
 4. Rosette-Disrupting Effect of an Anti-Plasmodial Compound for the Potential Treatment of Plasmodium falciparum Malaria Complications. Ch’ng JH, Moll K, Quintana MDP, Chan CLS, Masters E, Moles E, Liu J, Eriksson AB, Wahlgren M. Nature Scientific Reports 2016; 6, 29317.
 5. Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1. Moll K, Palmkvist M, Ch’ng J, Kiwuwa MS, Wahlgren M. PLoS ONE. 2015; 10(12): e0145120.
 6. Microbial hara-kiri: Exploiting lysosomal cell death in malaria parasites. Ch’ng JH, Ursing J, Tan KSW. Microbial Cell 2015; 2: 57-58.
 7. Validation of a Chloroquine-Induced Cell Death Mechanism for Clinical Use against Malaria. Ch’ng JH, Lee YQ, Gun SY, Chia WN, Chang ZW, Wong LK, Batty KT, Russell B, Nosten F, Renia L, Tan KSW. Cell Death Dis 2014; 5: e1305.

View all at http://medicine.nus.edu.sg/mbio/doc/publications/junhong_pub.pdf