Claudia Stocks

Claudia Stocks

PhD, Institute for Molecular Bioscience, University of Queensland
claudia.stocks [at] ntu.edu.sg

Claudia grew up in the Blue Mountains of NSW, Australia. After moving to the Inner West of Sydney, Claudia completed a Bachelor of Adv. Science (Medical microbiology and Immunology) at the University of New South Wales. Her Honours project in the laboratory of Prof. Ruiting Lan focussed on the development of a new diagnostic test to identify infection with emerging strains of Bordetella pertussis (whooping cough). After taking over a year off to work and travel, Claudia moved to Brisbane to undertake a collaborative PhD project across the laboratories of Prof. Matthew Sweet (Institute for Molecular Bioscience) and Prof. Mark Schembri (School of Chemistry and Molecular Biosciences) at the University of Queensland. This project examined the innate immune antimicrobial pathway of zinc toxicity, and its role in defence against Uropathogenic E. coli. In her spare time, Claudia enjoys listening to audiobooks and podcasts, walking her dog Snickers, and watching far too much Netflix.

Claudia continues to be fascinated by both sides of complex host-pathogen interactions – innate immune antimicrobial pathways and the strategies deployed to attempt to destroy pathogens, as well as the various mechanisms utilised by these pathogens to evade and subvert these responses. Currently, she is examining interactions between the human pathogen Enterococcus faecalis and neutrophils, particularly in the context of diabetes.

1. An alloy of zinc and innate immunity: galvanizing host defence against infection. von Pein JB, Stocks CJ, Schembri MA, Kapetanovic R, Sweet MJ. Cell Microbiol. (2020).
2. LPS-inducible SLC30A1 drives human macrophage-mediated zinc toxicity against intracellular Escherichia coli. Stocks CJ, Pein Jv, Curson JEB, Rae J, Phan M-D, Foo D, Bokil NJ, Kambe T, Peters KM, Parton RG, Schembri MA, Kapetanovic R, Sweet MJ. J Leukoc Biol. (2020)
3. Uropathogenic Escherichia coli employs both evasion and resistance to subvert immune-mediated zinc toxicity for dissemination. Stocks CJ, Phan MD, Achard MES, Nhu NTK, Condon ND, Gawthorne JA, Lo AW, Peters KM, McEwan AG, Kapetanovic R, Schembri MA and Sweet MJ. PNAS USA (2019).
4. Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. Kapetanovic R, Bokil NJ, Achard ME, Ong CY, Peters KM, Stocks CJ, Phan MD, Monteleone M, Schroder K, Irvine KM, Saunders BM, Walkeer MJ, Stacey KJ, McEwan AG, Schembri MA, Sweet MJ. FASEB J. (2016).
5. For when bacterial infections persist: Toll-like receptor-inducible direct antimicrobial pathways in macrophages. Stocks CJ, Sweet MJ, Schembri MA, Kapetanovic R. J Leukoc Biol. (2018).