Sumitra Debina Mitra

Sumitra Debina Mitra

M.Sc. St. Xavier’s College
B.Sc. (Hons) K.C. College

Sumitra completed her Master’s in Biotechnology from St. Xavier’s College, Mumbai and worked for a year at P.D. Hinduja National Hospital on drug resistance in Helicobacter pylori in the local population. She also studied the prevalence carbapenemase producing Enterobacteriaceae. Sumitra is passionate about two things: microbiology and animals, having two pet dogs and fostering a number of strays back home. She loves Singapore for its vibrant lifestyle and multicultural experience. In the lab, Sumitra’s Ph.D. project focuses on the mechanism of Sortase A localization on the cell surface of Enterococcus faecalis.

Sortases are enzymes responsible for the sorting and covalent anchoring of surface proteins to the cell wall of Gram positive bacteria such as E. faecalis. Sortases are now being viewed as potential drug targets due to their role in virulence factor attachment to the cell wall, especially Sortase A (SrtA). While the function of SrtA is well understood, the mechanism of the enzymes focal localization during bacterial cell cycle is unclear. Our study aims to:

  1. Elucidate protein interacting partners that help mediate localization of SrtA
  2. Elucidate the functional residues of SrtA responsible for focal virulence factor assembly.

1. Mitra, S.D., Afonina, I. and Kline, K.A. (2016) Right Place, Right Time: Focalization of Membrane Proteins in Gram-Positive Bacteria. Trends in Microbiology 24(8): 611-621.  
2. Mitra, S., Kazi, M., Panchal, M., Rodrigues, C. and Shetty, A. (2015) Evaluation of Carba NP test for rapid detection of carbapenemase producing Enterobacteriaceae. Indian Journal of Medical Microbiology, 33(4), p.603.